Prednisone uses must be under controlled by Doctor.
Prednisone is a prodrug that is converted glucocorticoids by 11beta-hydroxysteroid dehydrogenase in the liver to the active form, prednisolone. It is used to treat certain inflammatory diseases (such as severe allergic reactions) and (at higher doses) some types of cancer, but it has many significant side effects. It is usually taken orally but can be delivered by intramuscular injection or intravenous injection.
Here are the classification about the contents of prednisone:
Class of steroid compounds are lipid compounds that have specific chemical structure which has three cyclohexane rings and one cyclopentane ring. A steroid molecules produced naturally by the body's adrenal cortex is known as a corticosteroid compound. Corticosteroids alone are classified into two based activities, namely glucocorticoids and mineralocorticoids. Glucocorticoids have a role in glucose metabolism, whereas mineralokortikosteroid have salt retention.
In humans, the major natural glukortikoid is cortisol or hydrocortisone, while the main mineralocorticoid is aldosterone. In addition to the natural steroid, has been widely disintetis synthetic glucocorticoids, which includes an important class of drug because it is widely used, especially for the treatment of diseases of inflation. Examples include dexamethasone, prednisone, methyl prednisolone, triamcinolone and betamethasone (Ikawati, 2006).
Corticosteroids work by affecting the rate of protein synthesis. Hormone molecule enters the cell through the plasma membrane by passive diffusion. Only in target tissue hormones react with receptors specific proteins in the cytoplasm of cells and form a steroid-receptor complex. This complex komformasi change, then move toward the nucleus and binds to chromatin.
This bond stimulates transcription of synthetic RNA and specific proteins. Induction of protein synthesis that will produce physiological effects of steroids (Darmansjah, 2005). According to Theodore (1994) on indications, contraindications, drug interactions, side effects of prednisone uses, namely:
Indications: Adrenal insufficiency, nephrotic syndrome, collagen disease, bronchial asthma, heart disease, rheumatism, lymphocytic leukemia, lymphoma, cerebral edema, allergic konjungtifitis, otitis externa, skin diseases.
Contra indications: Systemic fungal infections, hypersensitivity, giving caution in patients with colitis ulserasif, renal insufficiency, hypertension, infection pyrogenic
Drug interactions: Fenitan, phenobarbital, ephedrine, rifampin, increased clearance of these drugs. Changing the anti-coagulant response when given together, hiperkakemia incidence increases when given with calcium sparing diuretics.
Prednisone side effects : Nausea, weight loss, acne, weakness, thinning of bones, fluid retention, ulceration reptikum, confused.